Phepelo ea lihlahisoa Dihexa CAS 1401708-83-5

Tšebeliso:

DIHEXA (PNB-0408), reagent ea oligoplase, ke analogue ea IV ea vascular tensionin IV e nang le ts'ebetso ea molomo le thibelo ea mali-bokong.Dihexa e nang le botsoalle bo phahameng le matla a kopanya hepatocyte growth factor (HGF), ChemicalBookkd value ke 65PM, mme e ntlafatsa mosebetsi oa eona ho amohela C-MET.Dihexa e bonts'a ts'ebetso e ntle ea anti-ejaculation le ho ntlafatsa ts'ebetso ea kelello mefuteng ea liphoofolo.Dihexa e na le monyetla oa ho ithuta lefu la Alzheimer.

Dihexa e tlama ka kamano e phahameng ho HGF le bobeli ba dihexa le motsoako oa motsoali oa eona Norleucine 1-AngIV e etsa hore c-Met phosphorylation e be teng ka har'a likarolo tse nyenyane tsa HGF le ho eketsa ho hasana ha lisele tse itšetlehileng ka HGF.Ho feta moo, dihexa le Nle1-AngIV li kenya hippocampal spinogenesis le synaptogenesis e tšoanang le HGF ka boeona.Dihexa e thibela ka katleho HGF dimerization ho 1 μM. Ha dihexa e le 1 nM le 10 pM feela e sa sebelise c-Met, e matlafatsa ka mokhoa o hlakileng matla a HGF ho 1.25 le 2.5 ng / mL ho kenya c-Met.

Dihexa e na le nako e telele ea ho potoloha halofo ea bophelo.Dihexa e bonts'a ts'ebetso ea kelello. Dihexa e khutlisa likhaello tsa thuto ea sebaka se itšetlehileng ka scopolamine.E ntlafatsa thuto ea sebaka ho likhoto tse tsofetseng.Dihexa e kenyelletsa spinogenesis ho li-neuron tsa hippocampal tse hlahisitsoeng.