Inhibitor GW0742 CAS 317318-84-6 Phofo e tšoeu

Andarine (S-4) ke motsoako o tsoang ho arylpropionamide [S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl) -propionamide] pele e hlalositsoe ke Yin et al.ho ba modulator ea androgen receptor (SARM) e khethiloeng.Andarine (S-4) e bontšitsoe ka lithuto tsa in vitro le in vivo hore e be agonist e sebetsang ea anabolic, ntle le litla-morao hangata tse amanang le anabolic-androgenic steroids, tse amanang haholo-holo le substrate affinity bakeng sa 5α-reductase ho hlahisa DHT ho prostate.
Mosebetsi oa pharmacological oa andarine o fana ka maikutlo a bokhoni bo boholo ba andarine ho nts'etsopele ea li-SARM tse fumanehang tleliniking, e fanang ka melemo e ikhethang ea phekolo ho feta balekane ba bona ba steroidal le monyetla o monate oa ho laola ka tsela e fapaneng liphello tsa androgen meleng e fapaneng ea sepheo, kahoo ho fokotsa ho kena-kenana le maemo a tloaelehileng. .Kahoo, andarine e na le ts'episo ea liteko tse tsoetseng pele tsa kliniki tse ikemiselitseng ho phekola maloetse a amanang le lilemo le ho loantša matšoao a mafu a matla a kang sarcopenia le kankere ea cachexia.
Andarine ke agonist ea khetho ea nonsteroidal androgen receptor (AR) e nang le Ki ea 4 nM.Andarine e bonts'a ts'ebetso ea anabolic e matla le e sebetsang 'me e fella ka ts'usumetso e itšetlehileng ka tekanyo ea kholo ea prostate, seminal vesicles, ka ho latellana.Andarine e na le matla a antiosteoporotic.
Andarine (eo pele e neng e tsejoa e le GTx-007; S-4; GTx007; S4) ke agonist ea molomo ea bioactive le e khethollang e seng ea steroidal androgen receptor (AR), haholo-holo e khethollang androgen receptor modulator (SARM), e nang le thuso e ka bang molemo ho senya mesifa. le lefu la ho fokola ha masapo.E kenya tšebetsong AR ka Ki ea 4 nM mme e khetha lithane bakeng sa litho tsa anabolic.Andarine e ntse e batlisisoa bakeng sa ho phekola maemo a kang ho senyeha ha mesifa, lefu la ho fokola ha masapo le benign prostatic hypertrophy.Ka mohlala oa phoofolo ea benign prostatic hypertrophy, andarine e ile ea bontšoa ho fokotsa boima ba prostate ka katleho e tšoanang le finasteride, empa ntle le ho hlahisa phokotso leha e le efe ea mesifa ea mesifa kapa litla-morao tse khahlanong le androgenic.