HU-210 CAS NO: 112830-95-2

HU-210 ke (--) enantiomer ea 11-OH-D 8-THC-DMH, e nang le hoo e batlang e le mesebetsi eohle ea li-cannabinoids, athe (+) enantiomer, e bitsoang HU-211, ha e sebetse e le cannabinoid, empa e sebetsa e le cannabinoid joalo ka mohanyetsi oa NMDA ea nang le litlamorao tsa neuroprotective.

HU-210 e ka 'na ea khothalletsa ho ata, empa eseng phapang, ea embryonic hippocampal neural stem cell le lisele tsa progenitor ka ho kenya CB 1 receptor, G i / o protheine, le pontšo ea ERK ka tatellano.Keketseho ena ea methapo ea kutlo e boetse e bonts'a tlhoko ea litlamorao tse khahlanong le ho tšoenyeha le khatello ea maikutlo.

Hammoho le tse ling tse entsoeng cannabinoids, tse kang WIN 55,212-2 le JWH-133, HU-210 e sireletsa khahlanong le ho ruruha ho bakoang ke lefu la Alzheimer's-associated beta amyloid, ho phaella ho thibela ho senyeha ha kelello le ho lahleheloa ke matšoao a neuronal.Phello ena e khahlanong le ho ruruha e bakoa ke ts'ebetso ea li-cannabinoid receptors, tse thibelang ts'ebetso ea lisele tsa microglia tse ruruhang.Ntle le moo, li-cannabinoids li felisitse ka botlalo neurotoxicity e amanang le ts'ebetso ea lisele tsa microglial mefuteng ea likhoto.

HU-210 ke sebolaya-mahlaba se matla se nang le litlamorao tse ngata tse ts'oanang le tsa tlhaho tsa THC.

LD50 ea molomo ea HU-210 ke 5,000mg/kg ho likhoto le 14,200mg/kg ho mebutlanyana.LDLO (lethal dose e tlase ka ho fetisisa e bolaeang) ea HU-210 ho batho ke 143mg/kg.LD50 ea caffeine e hakanngoa hore ke 150-200 mg / kg.Delta-8-THC LD50 ha e so netefatsoe.Phuputsong ea 1973, litšoene le lintja tse fuoeng 9,000 mg / kg ea Delta-8-THC li ne li sa bolaee.